Last Updated: Wednesday, 30 September 2015

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  • Defining molecular basis for longevity traits in natural yeast isolates:
  • A new study pinpoints a consistent set of genes and pathways underlying variations in yeast lifespan. Vadim Gladyshev and co-workers [along with collaborators from the University of Washington in Seattle] analyzed 22 Saccharomyces cerevisiae yeast strains with diverse lifespans and habitats, looking to identify genomic signatures associated with natural variations in longevity. They observed a number of factors that characterized the longest-lived strains, including the upregulation of aerobic respiration, and found that interactions between genes and the environment were key. They also showed that factors associated with increased longevity in yeast strains do not necessarily degrade the fitness of those strains in the wild, and that longevity can be influenced through diet. The study thus paints a more complete picture of how environmental factors trigger changes-some hard-wired in the genome-that have real consequences on aging and longevity.
  • Kaya A, Ma S, Wasko B, Lee M, Kaeberiein M, Gladyshev VN. (2015) Defining molecular basis for longevity traits in natural yeast isolates. npj Aging and Mechanisms of Disease, In Press.
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