Vadim Gladyshev Lab     

Selenium and Redox Biology
DNA Helix in the Beadle Center

Welcome to Gladyshev Lab Website



Areas of interest:

  • Thiol-based redox regulation and signaling

  • Identity and functions of selenocysteine-containing proteins

  • Mechanism of cancer prevention by selenium

  • Bioinformatics

  • Redox biology

  • Aging

RSS

Latest publications from the lab


dbTEU: a protein database of trace element utilization. Zhang Y., Gladyshev V.N. (2010) Bioinformatics, Jan 6. [Epub ahead of print]

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. Gerashchenko M.V., Su D., Gladyshev V.N. (2009) J Biol Chem., Dec 14. [Epub ahead of print]

Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Sengupta A., Carlson B.A., Labunskyy V.M., Gladyshev V.N., Hatfield D.L. (2009) Biochem Cell Biol., 87: 953-961.

General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni and Se. Zhang Y., Gladyshev V.N. (2009) J Biol Chem., 285: 3393-3405.

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. Carlson B.A., Yoo M.H., Sano Y., Sengupta A., Kim J.Y., Irons R., Gladyshev V.N., Hatfield D.L., Park J.M. (2009) BMC Immunol., 10: 57.

Structural analysis of cysteine S-nitrosylation: A modified acid-based motif and the emerging role of trans-nitrosylation. Marino S.M., Gladyshev V.N. (2009) J Mol Biol., 395: 844-859.