Last Updated: Monday, 22nd August 2016

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  • Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.
  • Different theories posit that aging is caused by molecular damage, genetic programs, continued development, hyperfunction, antagonistic pleiotropy alleles, mutations, trade-offs, incomplete repair, etc. Here, Dr. Gladyshev discusses that these ideas can be conceptually unified as they capture particular facets of aging, while being incomplete.
  • Gladyshev VN. (2016) Aging Cell, 15, 594-602.
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