News from the Lab

Our paper on the genetic links between COVID19 and aging is published!
October 5, 2021

Our new study, published in Communications Medicine, reveals that genetic variation that supports longer life is significantly associated with a lower risk of COVID-19 infection and hospitalization. We also find an interesting link between COVID and the Notch signaling pathway. Congrats to graduate student Albert and everyone involved!

Embryonic rejuvenation paper published!
June 25, 2021

Our new study, published in Science Advances, reveals that mammalian embryogenesis is characterized by an epigenetic rejuvenation period, opening up avenues for future work on rejuvenation. Congrats to Csaba and the rest of the team!

Some news coverage of the article:
Science News
Interesting Engineering

National Academy of Sciences Election
April 26, 2021

Vadim was elected to the National Academy of Sciences in April 2021. Congratulations Vadim! Click here to learn more.

Lab Alumni Start Independent Groups
April 2021

Recent alumni from the lab have moved on to faculty positions and started their own groups in the US and in Europe:
Alaattin Kaya has started his group at Virginia Commonwealth University.
Sun Hee Yim is starting a lab at Texas Tech University.
Marco Mariotti is starting a lab at Universitat de Barcelona.

Iron Bolt Award
February 7, 2020

Vadim received the Iron Bolt Award at the Gordon Research Conference on Oxygen Radicals in February 2020. Click here to learn more about the Iron Bolt.

Dr. Gladyshev Debates – Undoing Aging
May 15, 2019

Dr. Gladyshev and Dr. Aubrey de Grey debate the feasibility of comprehensive damage repair at ‘Undoing Aging 2019’ in Berlin, Germany. To watch the debate click here.

April 5, 2017

Our new paper entitled “Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions” is receiving media attention. To read more click here.

Diet Paper Featured in Harvard Magazine
March 10, 2017

Sang Goo Lee’s (et al) paper entitled, “Age-associated molecular changes are deleterious and may modulate life span through diet,” is featured in the February 2017 issue of Harvard Magazine. To read more on this feature, click here.

ARS “Redox Pioneer” Feature
July 11, 2016

ARC Cover
Dr. Gladyshev is featured and recognized as a Redox Pioneer in Volume 25, Issue 1 of the ARS Journal. To discover more about this article, click here.

11th Annual Symposium on Aging
June 20, 2016


Last Friday, Dr. Gladyshev was invited to speak at the 11th Annual Harvard/Glenn Symposium on Aging. Every year, the Paul F. Glenn Center for the Biology of Aging hosts the Harvard Symposium on Aging at Harvard Medical School. The mission of the symposium is to educate the wider research community about advancements in this fast-paced field and to stimulate collaborative research in this area.

Following the symposium, Dr. Gladyshev was gifted the Paul F. Glenn Aging award (pictured above) by the Center’s Co-Directors, Drs. Bruce Yankner and David Sinclair, along with the President and Director of the Glenn Foundation for Medical Research, Mark R. Collins.

More information and photos of the day’s event can be viewed here.

BWH Research News
June 16, 2016

research news

Dr. Gladyshev is featured in this week’s BWH Clinical & Research News. Read more regarding his passion for aging research here.

Congratulations to Dr. Siming Ma
June 7, 2016


The Gladyshev lab would like to congratulate Dr. Siming Ma on his 2016 graduation from Harvard University. Above, Dr. Ma is pictured with his advisor, Dr. Gladyshev, at his May 26th Hooding Ceremony. It was a pleasure to have Dr. Ma as a part of our team for four productive years! We wish him amazing success in his future endeavors.

Grad Student Successfully Defends PhD Thesis
April 15, 2016

Siming Ma Defense

Siming Ma, a graduate research student in our lab, successfully defended his thesis titled, “Molecular Patterns and Signatures of Longevity” today. Siming joined the lab in April 2012 as a graduate student of the Harvard Biological and Biomedical Sciences (BBS) PhD program. For his thesis research, Siming developed and used bioinformatics tools to analyze the variation of gene expression, metabolites and elements across different species of mammals, flies and yeasts, to identify the molecular patterns associated with species natural lifespans. During this time, he published 3 papers as first author and 6 papers as contributing author. Following his graduation, Siming will join the Genome Institute of Singapore to focus on cancer biology. Congratulations Dr. Ma!

The Nature of Aging
January 26, 2016

Flyer - The Nature of Aging

On Monday, Jan. 25th, Dr. Gladyshev hosted a lab only event discussing the nature of aging. Guest lecturers were invited to propose their theories on aging in relation to their current research. The event lead to an afternoon of insightful discussions on this very hot topic.

SPS Publication Makes Cover of September’s Genome Research
September 2, 2015

GR Cover
Yesterday, the Genome Research September issue was released much to the delightful surprise of our colleague, Dr. Marco Mariotti. The September cover features artwork painted by Dr. Mariotti’s mother, Milena Biolcati Rinaldi. The cover illustration was inspired by the concepts of Mariotti et al’s SPS paper, which is published in the September issue.

More information on the SPS publication can be found here.

Update on Former Lab Members
July 9, 2015

What is life like post-Gladyshev lab? Two former lab members share their current career accomplishments.



Vyacheslav Labunskyy, Ph.D.
Lab Member from 2003-2014
Dr. Labunskyy is currently an Assistant Professor in the Department of Dermatology at Boston University School of Medicine located in Boston, MA. Research in the Labunskyy lab is focused on the biology of aging and studying the mechanisms that underlie aging in humans using skin aging as a model system.

Byung Cheon Lee, Ph.D.
Lab Member from 2006-2014
Dr. Lee is currently an Assistant Professor in the Division of Biotechnology, College of Life Sciences and Biotechnology at Korea University located in Seoul, S. Korea. Dr. Lee’s research is focused on Redox Biology (redox protein biochemistry; functional regulation by redox protein; and the development of sensing system to redox status change) and Aging Biology (mechanism of lifespan extension by methionine restriction diet; and the regulation of aging by hydrogen sulfide and sulfur metabolism).

“Molecular Causes of Aging” makes Top-20 on Serious Science
December 11, 2014

Dr. Gladyshev speaks on oxidative species, origins of senescence, and cumulative damage with Serious Science. The video makes it to #6 on the Top-20 list.

Boston Globe Features Aging Research
October 31, 2013

The Gladyshev lab’s reserach on aging has been featured in the online version of the Boston Globe.



Dr. Gladyshev – 2013 Pioneer Award Recipient
October 2, 2013

NIH Pioneer Award
Dr. Gladyshev has been awarded the 2013 NIH Director’s Pioneer Award for his project proposal entitled, “Mechanisms of lifespan control.” The Pioneer Award “complements NIH’s traditional, investigator-initiated grant programs by supporting individual scientists of exceptional creativity, who propose pioneering – and possibly transforming approaches – to major challenges in biomedical and behavioral research.” Dr. Gladyshev shares this year’s honor with 11 other U.S. scientists.

Click to learn more about the Pioneer Award & Dr. Gladyshev’s project.

Brandt’s Bat Genome Paper NEWS
August 21, 2013

Inge Seim et al’s paper entitled, “Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii,” currently published in the journal of Nature Communications, has received several online news features. Below are links to some of the news sources.



LiveScience: Longest-Living Bat Holds Clues to Longevity

Business Insider: How Tiny Bats Can Help Us Extend Human Life

Postdoctoral Fellow Receives NIH Pathway to Independence Award (K99/R00)
January 14, 2013

Vyacheslav Labunskyy, Ph.D.
In October of 2012, Vyacheslav Labunskyy, Ph.D. was awarded a prestigious K99/R00 Pathway to Independence Award by the National Institute on Aging (NIA) to support his research on the role of the unfolded protein response in aging. Dr. Labunskyy’s research interests include the basic mechanisms of aging and understanding the biological processes that underlie age-related diseases. In his studies, Dr. Labunskyy uses a combination of genetic, molecular and biochemical approaches to characterize the mechanisms by which ER stress response signaling regulates longevity and how protein folding capacity and redox state in the ER change with age in the yeast Saccharomyces cerevisiae.

NMR Publication Makes Headlines
October 14, 2011; Updated November 15, 2011

The recently published naked mole rat (NMR) paper in Nature has been making headlines since being available online on Wednesday (Oct. 12th) afternoon. Below are a few selected highlights from some of the US’ major news publications.

Bloomberg Businessweek: Naked Mole Rat Genome Map May Aid in Cancer, Aging Research

Harvard Gazette: Cancer clues from another species

NPR: Naked Mole Rat’s Genetic Code Laid Bare

USA Today: Cancer-free rodent genome may hold key to aging, disease

Post-doc Receives an Ellison/AFAR Fellowship Award in Aging
August 19, 2011

Vyacheslav Labunskyy, Ph.D. has been chosen as one out of fifteen postdoctoral fellows in the country to receive the 2011 Ellison Medical Foundation/AFAR Postdoctoral Research in Aging Award. The Ellison Medical Foundation created the award, in partnership with the American Federation for Aging Research (AFAR), “to encourage and further the careers of postdoctoral fellows with outstanding promise in the basic biological and biomedical sciences relevant to understanding aging processes and age-related diseases and disabilities. The award is intended to provide significant support to permit these postdoctoral fellows to become established in the field of aging.”

Dr. Labunskyy’s project seeks to better understand the link between endoplasmic reticulum stress and aging, using the budding yeast Saccharomyces cerevisiae as a model system. Results of his research may have broad implications for many age-related diseases associated with aberrant folding and accumulation of misfolded proteins and may provide a rational basis for new therapeutic strategies to delay the aging process in humans.

Dr. Gladyshev Receives Prestigious NIH MERIT Award
August 2, 2011

The National Institute of General Medical Sciences (NIGMS) has awarded Dr. Gladyshev the highly selective National Institute of Health (NIH) MERIT (Method to Extend Research in Time) Award. The award, which was initiated in 1987, awards less than 5 percent of NIH-funded investigators. Investigators who are leaders in their field and demonstrate “superior competence and outstanding productivity in research endeavors” are awarded extended grant support for up to ten years to their current grant without having to submit a traditional competing renewal application.

Dr. Gladyshev’s project relating to thioredoxin reductases and redox regulation was selected for this prestigious MERIT award. Dr. Gladyshev believes that the MERIT award will allow him and the lab to develop a more general approach in addressing critical issues of thiol-based redox control and to study its basic properties and specific examples of redox regulation, both of which have been at the core of research interests in the Gladyshev lab.

Another Graduate Student Successfully Completes Ph.D. Program
June 30, 2011

Marina Kasaikina, Ph.D.

On June 17th, Marina Kasaikina successfully defended her thesis entitled, “Understanding of functions of selenoproteins and dietary selenium by using animal models,” at her home university, the University of Nebraska, Lincoln. Since 2006, Marina has worked in the lab as a graduate student researching selenium supplementation and consequences of selenium deficiency. During this time, she also published 4 papers. Following her August graduation, she will continue her research on cancer and selenium supplementation as a researcher in the lab. Congratulations, Marina, on your accomplishments!

Graduate Student Researcher Receives Ph.D. Degree
May 6, 2011

Mikalai Malinouski, Ph.D.

Congratulations are in order to Mikalai Malinouski, graduate research student in the Gladyshev lab since August 2005, for completing and successfully defending his Ph.D. thesis earlier this season. Under the guidance of Dr. Gladyshev and Dmitri Fomenko, Ph.D., Mikalai graduated with a Ph.D. in Biochemistry at the University of Nebraska-Lincoln on May 6, 2011.

Mikalai’s Ph.D. thesis is entitled, “Understanding of Selenium Utilization and Redox Homeostasis Through Imaging and High-throughput Approaches.” During his Ph.D. course work, he was able to publish 3 papers and was also involved in various projects, including: studying the transportation and regulation of trace elements in human cells and tissues; developing a high-throughput method for ionomic profiling in mammalian cells; detecting new genes involved in trace element metabolism and identified candidate genes that uniquely regulate metabolism of particular trace elements.

We are also happy to announce that Mikalai will continue to further his research on thioredoxin reductases and selenoproteins as a Postdoctoral Fellow in the Gladyshev lab.

AAAS Names Dr. Gladyshev as a 2011 Fellow
Jan. 11, 2011

Vadim Gladyshev

The American Association for the Advancement of Science (AAAS) has recently announced its 2011 Fellows, naming Vadim Gladyshev, Ph.D. as one of them. Only 15 Harvard faculty members were elected as Fellows this year. Vadim joins three previous honorees from the Division of Genetics, Department of Medicine at Brigham & Women’s Hospital: Raju Kucherlapti, Ph.D., Claude P. Lechene, M.D., Ph.D., and Steve Elledge, Ph.D. in receiving this prestigious honor.

Read more…

Lab Events

Annual Lab Retreat. Barnstable, MA.
October, 2023

Trip to Cape Cod 2023.

Summer Lab Outing. Newton, MA.
July, 2023

Golf Lesson.

Annual Lab Retreat. Falmouth, MA.
October 27-28, 2022

Trip to Cape Cod 2022.

Lab Outing. Rail Explorers. RI.
June 28, 2022

Trip along the coastal railway of Aquidneck Island.

Skating Night at Kendall square!
March 5, 2022

The lab members had fun at Kendal square skating rink.

Lab Retreat in Cape Cod!
Oct 8, 2021

The lab had a phenomenal weekend retreat in Cape Cod, filled with great food, biking, and a couple fierce board games!





Kayaking on the Charles!
June 28, 2021

The whole lab went on a kayaking trip on the Charles River (separating Cambridge and Boston) followed by a great lunch at Shy Bird!






Farewell Marco!
January 29, 2021

The lab gathered to say farewell to instructor Marco before his departure for Spain, where is starting his own genomics lab at Universitat de Barcelona!


Farewell Jose!
June 18, 2020

The Gladyshev lab gathered in a COVID-safe fashion to say goodbye to postdoc Jose before his departure for Portugal.


End of Summer 2017 Excursion
September 5, 2017

A few members of the Gladyshev lab took a day trip to North Conway, NH during Labor Day weekend to enjoy antique trains, hiking and waterfalls.

Happy Women’s International Day 2017
March 8, 2017

The Gladyshev lab would like to wish all women in the world a wonderful Women’s International Day! Below is a photo of Dr. Gladyshev with some of the women that make up his international team.


3rd Annual Lab Thanksgiving Celebration
November 23, 2016

Pictured are some members of the Gladyshev, Liao, and Loscalzo labs at their 3rd Annual Thanksgiving Potluck.

Lab Thanks 2016

Apple-picking at Shelburne Farm
October 24, 2016

Some member’s of the lab took a Sunday drive to the outskirts of Boston to enjoy a wonderful sunny day apple-picking at Shelburne Farm. For one grad student, this was the first time experiencing such an outing, and therefore, truly enjoyed this fall New England tradition.

Lab AP 2016

Summer Lab Outing to Mt. Major
June 29, 2016

The lab’s annual summer outing this year was a hike on Mt. Major. Atop the summit, the lab enjoyed a guitar serenade by postdoc Marco, singing Happy Birthday (in French!) to postdoc Adeline, and enjoying the spectacular view of New Hampshire at 544 meters high! The day-trip concluded with ice cream to cool-off from the intense hike and heat.


Lab Excursion to Georges Island
June 29, 2015

The Gladyshev Lab took their annual lab summer celebration out to the Boston Harbor Islands.

Lab Georges Island 2015

Happy Thanksgiving!!
November 26, 2014

Some of the members of the Gladyshev, Liao, & Loscalzo labs pictured at the annual Thanksgiving lab celebration.

2014 Thanks

2013 Lab BBQ Summer Kick-Off
June 15, 2013

Celebrating the start of summer at Larz Anderson Park.

2013 Lab BBQ

2012 Division Holiday Party
January 7, 2013

Members of the Division of Genetics celebrating the Holiday Season.

2012 Division Holiday Party

Division of Genetics 25th Anniversary BBQ
September 17, 2012

Members of the lab, along with fellow Genetics members and their family and friends, celebrated the 25th anniversary of the Division of Genetics with a kick-off BBQ at Larz Anderson Park.

BBQ at Larz Anderson Park

Memorial Day Weekend BBQ
May 29, 2012

The lab celebrated Memorial Day Weekend and the kick-off of summer with a BBQ and a few rounds of soccer.

Lab BBQ at Arsenal Park

BWH Division of Genetics Holiday Party
December 20, 2011

The Gladyshev Lab would like to wish everyone a safe, fun, and healthy holiday season!

Gladyshev lab taking part in the BWH Division of Genetics annual holiday party

Lab Bowling Night
October 18, 2011

Lab Bowling 2011

MFA Thesis Art Exhibition
May 5, 2011

MFA Helen
Members of the lab went out to support Vadim’s wife, Helen, in her completion of her MFA from the Massachusetts College of Art and Design. Helen, along with other fellow graduates, exhibited their thesis for an entire week at MassArt. Members of the lab were very impressed at her self portraits and sculptures, particularly at the fact that she has only been sculpting for a short time. The entire lab would like to congratulate Helen in her achievements. We are excited to see what she will do next.

Learn more about MassArt…

Past News: Click here to go to the Archives Section.