2020 Articles
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. (2020) Reprogramming to recover youthful epigenetic information and restore vision. Nature. 588(7836)
Zoonomia Consortium. (2020) A comparative genomics multitool for scientific discovery and conservation. Nature. 587(7833)
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. (2020) ARDD 2020: from aging mechanisms to interventions. Aging. 12(24)
Gerashchenko MV, Peterfi Z, Yim SH, Gladyshev VN. (2020) Translation elongation rate varies among organs and decreases with age. Nucleic Acids Res.
Santesmasses D, Castro JP, Zenin AA, Shindyapina AV, Gerashchenko MV, Zhang B, Kerepesi C, Yim SH, Fedichev PO, Gladyshev VN. (2020) COVID-19 is an emergent disease of aging. Aging Cell. 19(10)
Gerashchenko MV, Nesterchuk MV, Smekalova EM, Paulo JA, Kowalski PS, Akulich KA, Bogorad R, Dmitriev SE, Gygi S, Zatsepin T, Anderson DG, Gladyshev VN, Koteliansky VE. (2020) Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Scientific Reports. 10(1), 15473.
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Van Haelen Q, Witkowski J, Cohen AA. (2020) The conundrum of human immune system “senescence”. Mechanisms of ageing and development. 192, 10.1016/j.mad.2020.111357.
Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. (2020) MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 130(9), 4663-4687.
Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. (2020) Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 32(4), 107949.
Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. (2020) Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 191, 111316.
Anisimova AS, Meerson MB, Gerashchenko MV, Kulakovskiy IV, Dmitriev SE, Gladyshev VN. (2020) Multifaceted deregulation of gene expression and protein synthesis with age. Proc Natl Acad Sci U S A. 117(27), 15581-15590.
Lashkevich KA, Shlyk VI, Kushchenko AS, Gladyshev VN, Alkalaeva EZ, Dmitriev SE. (2020) CTELS: A Cell-Free System for the Analysis of Translation Termination Rate. Biomolecules. 10(6), 911.
Sanchez-Lopez C, Labadie N, Lombardo V, Biglione F, Manta B, Jacob R, Gladyshev VN, Abdelilah-Seyfried S, Selenko P, Binolfi A. (2020) An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo. Chemistry.
Galkin F, Mamoshina P, Aliper A, Putin E, Moskalev V, Gladyshev VN, Zhavoronkov A. (2020) Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning. iScience. 23(6), 101199.
Liberman N, O’Brown ZK, Earl AS, Boulias K, Gerashchenko MV, Wang SY, Fritsche C, Fady PE, Dong A, Gladyshev VN, Greer EL. (2020) N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Sci Adv. 6(17), eaaz4370.
Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. (2020) High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors.
Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM. (2020) Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 117(20), 10789-10796.
Zhang B, Podolskiy DI, Mariotti M, Seravalli J, Gladyshev VN. (2020) Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks. Aging Cell. 19(5), e13119.
Zhang B, Gladyshev VN. (2020) How can aging be reversed? Exploring rejuvenation from a damage‐based perspective. Advanced Genetics. 1(1), e10025.
Galkin F, Mamoshina P, Aliper A, de Magalhães JP, Gladyshev VN, Zhavoronkov A. (2020) Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities. Ageing Res Rev. 60, 101050.
Shindyapina AV, Zenin AA, Tarkhov AE, Santesmasses D, Fedichev PO, Gladyshev VN. (2020) Germline burden of rare damaging variants negatively affects human healthspan and lifespan. eLife 9, 53449.
Fernando R, Wardelmann K, Deubel S, Kehm R, Jung T, Mariotti M, Vasilaki A, Gladyshev VN, Kleinridders A, Grune T, Castro JP. (2020) Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol. 32, 101507.
Santesmasses D, Mariotti M, Gladyshev VN. (2020) Bioinformatics of Selenoproteins. Antioxid Redox Signal. 33(7), 525-536.
Kaya A, Mariotti M, Tyshkovskiy A, Zhou X, Hulke ML, Ma S, Gerashchenko MV, Koren A, Gladyshev VN. (2020) Molecular signatures of aneuploidy-driven adaptive evolution. Nat Commun. 11(1), 588.
Smekalova EM, Gerashchenko MV, O’Connor PBF, Whittaker CA, Kauffman KJ, Fefilova AS, Zatsepin TS, Bogorad RL, Baranov PV, Langer R, Gladyshev VN, Anderson DG, Koteliansky V. (2020) In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation. Mol Ther Nucleic Acids. 19, 252-266.
Santesmasses D, Mariotti M, Gladyshev VN. (2020) Tolerance to Selenoprotein Loss Differs between Human and Mouse. Mol Biol Evol. 37(2), 341-354.